Chloramphenicol and L-Phenylalanine Therapy in Experimental Klebsiella pneumoniae Infection in Mice. ∗

Abstract

Summary

Parenteral administration of phenylalanine in a dose equivalent to that of chloramphenicol enhanced the antibacterial effect of chloramphenicol in mice infected with Klebsiella pneumoniae. Larger doses of phenylalanine, however, reduced the drug's antibacterial efficacy. The interaction of phenylalanine and chloramphenicol is discussed in relation to bacterial and mammalian cell protein synthesis.