Abstract
Summary
To determine if DFP32-labeled isologous granulocytes behave kinetically in a fashion similar to autologous granulocytes, the size of the total blood granulocyte pool, the distribution of cells in the circulating and marginal compartments and the half-disappearance time of isologous granulocytes were determined in 6 pairs of normal subjects. In 2 pairs of normal subjects the entry of labeled isologous granulocytes into experimentally induced inflammatory exudates was investigated. The results were compared with previously reported studies in which autologous blood was infused.
The size of the total blood granulocyte pool and the distribution of cells in the circulating and marginal compartments were normal in all 12 of the subjects studied. However, in 5 of the 12 subjects the half-disappearance time was more rapid than normal. It is suggested that in these 5 subjects, naturally occurring granulocyte incompatibilities may have accounted for the rapid disappearance of cells from the circulation.
Labeled isologous granulocytes migrated into inflammatory exudates less readily than did labeled autologous granulocytes. This observation may be of significance in regard to the therapeutic efficacy of isologous leukocyte transfusion.
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