Abstract
Summary
The response of 56°;C heated adenovirus 2-protected RHF-1 cells to infection with vaccinia did not appear to depend upon the heating time of the pre-challenge virus, and this resistance was not mediated by an interferon-like substance. A completely different picture was obtained when corresponding experiments were performed with adenovirus heated at 100°;C. The 100°;C heated adenovirus not only induced the formation of an interferon-like substance in the cells but Its production also increased with the duration of heating. The difference in rate of vaccinia inhibition in the cells treated with adenovirus 2 heated at 100°;C for increasing time was reflected in the amount of interferon-like substance produced in the cells. Taken as a whole, these data suggested strongly that interferon provides perhaps most of the basis for cellular resistance in this system. The results bring out fundamental differences between the two systems which presumably have different mechanisms.
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