Abstract
Summary
Replacement of blood after a hemorrhage to 50 mm Hg mean arterial pressure with autologous, reconstituted autologous, and homologous blood results in a significantly higher venous hematocrit than expected, indicating shifting of red cells and plasma within the circulation. Mean arterial pressure, plasma volume, and concentration and total amount of protein were not significantly different from the “expected” values. When reconstituted homologous blood was used as the replacement there was a significant reduction in plasma volume and total protein in addition to a steep rise in venous hematocrit. Urticaria was seen in 25% of the dogs receiving homologous blood and in 63% receiving reconstituted homologous blood, supporting the idea that handling of the blood to be transfused produces a substance causing urticaria. In the present experiments reconstituted blood, whether homologous or autologous, caused the loss of fluid and protein from the circulation.
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