Effect of X-Rays on Hemolysin Plaque Forming Cells. ∗

Abstract

Summary

All measured parameters of the primary antibody response of C57L × A/He mice injected with sheep red cells were uniformly depressed by 500 R of X-ray. With adequate X-ray doses, the production of antibody forming cells was radiosensitive, irrespective of the several time intervals employed between X-ray and antigenic stimulation. At lower X-ray doses the numbers of hemolysin plaque forming cells are clearly influenced by this time interval. A bi-phasic response to X-rays in the production of antibody forming cells was demonstrated, i.e., a relatively insensitive period in between two sensitive periods.