Abstract
Summary
Thymectomized and sham-thymectomized mice were lethally X-irradiated and given syngeneic and allogeneic bone marrow. Whereas the irradiated syngeneic chimeras failed to reject allogeneic skin grafts in the absence of the thymus, a secondary graft-versus-host disease developed with equal rapidity in both thymectomized and sham-thymectomized allogeneic chimeras. The possibility that bone marrow precursors of lymphoid tissue differentiate via different routes in irradiated syngeneic and allogeneic chimeras is suggested.
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