Abstract
Summary
Injection of small doses of colchicine (0.24 mg/kg) produces in mice and dogs a significant decline in whole blood folate activity for L. casei, within one to 3 hours. Incubation of normal human whole blood with colchicine in vitro for one hour also produces a significant decline in folate activity for the same organism. There was no evidence that colchicine acts as a competitive folate antagonist in the bacterial assay system. It is suggested that colchicine may act by interfering with the action of one or more enzymes which are concerned with the recycling of tetrahydrofolate.
Get full access to this article
View all access options for this article.