Abstract
That the increased output of uric acid following the use of atophan is accompanied by a diminution in the concentration of uric acid in the blood appears to be well established. As has been long known, salicylates induce an increased elimination of uric acid quite comparable to that produced by atophan; and it is of interest to learn whether this urinary increase is accompanied by a commensurate decrease in the blood.
We have found in seven cases that sodium salicylate in daily doses of 6 grams reduced the uric acid concentration of the blood to one half to one third of the initial concentrations.
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