Abstract
We have found that the administration of aqueous emulsions of the anterior lobe of the ox-pituitary, in doses of 0.5 grammes of fresh glandular tissue at intervals of two or three days, either directly into the tumor or hypodermically elsewhere, leads to a very marked increase in the rate of growth of the primary tumor in rats inoculated with the Flexner-Jobling carcinoma. The growth of small tumors is accelerated relatively more than that of large tumors.
This acceleration is only evidenced, however, at a certain stage in the growth of the tumor, subsequent to the twentieth day succeeding inoculations. The administrations do not enhance the tendency of the tumors to metastasize.
Liver-emulsion, similarly prepared and administered, does not cause any acceleration of the growth of carcinomata in rats.
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