Abstract
As is well known there is a rearrangement of the proteins of the blood in the course of immunization. The most notable change is an increase of the globulins and a decrease of the albumins. Such being the case, it seemed of interest to ascertain whether these modifications affected the rate of coagulability of the blood. Accordingly, the blood of a number of horses which have been immunized for months or years for the purpose of obtaining antisera against diphtheria, tetanus, meningitis, etc., was investigated from this point of view. Oxalated plasma was employed in the coagulation tests. The accompanying table gives the results of this investigation, and shows that the coagulation-time remains fairly constant in spite of marked variations in the proteins, that it is a factor which is not readily disturbed.
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