Abstract
If the uterus of a sensitized guinea-pig is rendered bloodless by transfusing it with Locke's solution, the sensitiveness of the uterine muscle to the foreign proteid is increased.
If the muscle is further freed from tissue lymph and from other diffusible tissue elements by repeated centrifugation in Locke's solution, the sensitiveness is greatly decreased.
If the serum and diffusible tissue elements thus removed are replaced in the muscle by repeatedly centrifuging the muscle in dilute normal guinea-pig serum, the sensitiveness is restored quantitatively.
This would seem to indicate that the reaction of the anaphylactic uterine muscle is dependent upon two factors: (a) a factor induced in the fixed cells by the process of sensitization, and (b) some normal serum component. It would also indicate the presence of a third element, (c) an antitoxic or anti-anaphylactic serum component.
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