Abstract
Summary
A constituent of an unidentified staphylococcus inhibited the multiplication and cytopathic effect of Sindbis, Western equine encephalitis and West Nile viruses in primary monolayer cultures of human amnion and human embryonic kidney cells. It did not inhibit other RNA and DNA viruses that were tested. Addition of the inhibitor 6 hours after infection of human amnion cell cultures with Sindbis virus significantly depressed viral replication. The inhibitor conferred only transient protection on primary monolayer cultures of chick and mouse embryo cells infected with Sindbis virus. The physico-chemical properties of the inhibitor that have so far been determined are compatible with those of a polysaccharide.
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