Abstract
Summary
Administration of D-glucosamine or 2-desoxy-D-glucose suppressed erythropoietin formation in hypoxic rats. No evidence was found to account for this depression on the basis of oxygen supply or consumption, and it is therefore attributed to a competitive inhibition of glucose phosphorylization. The inhibition of erythropoietin formation by the hexose analogues could be the result of their interference with the synthesis of the carbohydrate moiety of the erythropoietin molecule, or it could imply a rate regulating role of glycolysis in erythropoietin formation.
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