Abstract
Summary
Caloric restriction studies in Swiss, DBA/2, and BALB/c mice infected with Friend leukemia virus (FLV) have indicated that loss of host weight can markedly affect the extent of virus-induced splenomegaly, but does not noticeably affect the titer of recoverable virus in plasma or spleens from these animals. It was concluded that host weight change is important and should be considered when using FLV-induced splenomegaly in chemotherapy trials. The effect on FLV-induced splenomegaly of 2 compounds, porfiromycin and 1-methyl-1-nitrosourea, were evaluated in the light of these findings.
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