Effect of Poliovirus Infection on Histone Synthesis in the HeLa Cell. ∗

Abstract

Summary

The distribution of incorporated C¹⁴-arginine was determined among fractions (acid soluble his tones, acid insoluble protein and DNA) of deoxyribonucleoprotein from HeLa cells. During the early stages of infection of cells with poliovirus, the synthesis of the his tones was stimulated. This was followed (third hour) by a depressed rate of synthesis of both histones and a markedly reduced incorporation of arginine into DNA. The interrelations of these effects of infection on components of the histone-DNA-RNA synthetic sequence of the host cell are considered.