Abstract
Summary
Micron- and submicron-sized crystals of tricalcium phosphate, of sand and of barium sulfate ingested by rats entered the intestinal epithelium. They then were distributed and deposited in various organs where tricalcium phosphate and sand incited inflammation and granulomas. Crystals of tricalcium phosphate had caused similar changes in a patient. Particles of these and of other supposedly inert, insoluble substances contained in widely used products enter the body by way of the enteric and respiratory tracts after inadvertent exposure to them or by their deliberate use.
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