Abstract
Summary
An anti-inflammatory granuloma assay in the adrenalectomized rat has been employed to evaluate the relative potency of various nonsteroidal compounds. Statistically significant responses have been observed, but dose-related responses were not obtained. Graphic estimations of the range of relative potencies using cortisol acetate as the standard with an assigned potency of 100 follows: chloropheniramine maleate, 28–55; dipyrone, 3–8; phenylbutazone, 2–16; aminopyrine, 2–14; cinchophen, 2–18; and antipyrine, 1–5.
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