Abstract
Summary
1) Normal bovine adrenal medulla can effect the following reactions in vitro: a) Transformation of a straight-chain precursor (acetate) into steroid tetracyclic structures; b) Double bond shifting from Δ5 to Δ4 with concomitant oxidation at C3; c) Introduction of -OH groups at specific sites of the pregnane nucleus and d) Conversion of C21 to C19 steroids. 2) It has consistently failed to metabolize cholesterol to corticosteroids. 3) It has shown in several steroid biosynthetic reactions a greater responsiveness to diphospho- and triphospho-pyridine nucleotides than the cortex.
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