Abstract
Summary
The localization of soluble and insoluble collagen fractions during the development of normal chick embryo tendon and granulation tissue in injured adult chick tendon was studied by the immunohistochemical technique. Antisoluble collagen antibody reacted only with the cytoplasm of young fibroblasts and with extracellular young collagen fibers. Reticulin fibers which precede the collagen and interfibrillar mucopolysaccharides did not react nor did other tissue structures. Antiinsoluble collagen antibody did not react with fibroblasts and reticulin fibers but did react with collagen bundles.
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