Chemical and Metabolic Changes of Hepatic Lipids from Rats Exposed to Chronic Radial Acceleration

Abstract

Summary

From weaning until 1 year of age female Sprague-Dawley rats were centrifuged at 3.6 and 4.7 g. Liver slices of these rats were incubated with C¹⁴-labeled acetate and its incorporation into fatty acids, nonsaponifiable lipids, and CO₂ was measured. When compared with tissue from control rats, liver slices of centrifuged rats exposed to 4.7 g showed an increased formation of C¹⁴-nonsaponifiable lipids. Comparable changes were not observed in rats exposed to 3.6 g. No significant alteration was noted for incorporation of acetate into fatty acids or CO₂. The total lipid content of the liver was decreased significantly in rats exposed to 4.7 g. The response evoked from long-term exposure affected synthesis of nonsaponifiable lipids whereas short-term exposure affected fatty acid synthesis.