Abstract
Summary
A phospholipase A preparation from cobra venom (Naja naja), made by heating the venom in neutral or acid solution at 100°C for 15 minutes, released histamine and SRS activities from chopped guinea pig lung, as did the unheated venom. The direct lytic factor of the venom which is required for venom hemolysis did not appear to be necessary for this release. Lysolecithin, which is formed by the action of phospholipase A on lecithin, also released histamine and SRS activities from chopped guinea pig lung. Suspensions of homogenized or lyophilized guinea pig lung did not release SRS activity when kept at 0°C but did release this activity when incubated at 37°C.
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