Abstract
Summary
Suckling mice and rats develop a hemorrhagic syndrome when infected with a low mouse passage strain of Thailand chikungunya virus. Studies of hemostasis revealed thrombocytopenia, prolonged bleeding time, prolonged clotting time and decrease in prothrombin time and factor V and factors VII + X. Attempts to modify the occurrence of hemorrhage by pretreatment with corticosteroids or antibiotics were unsuccessful. Animals treated with heparin appeared to be somewhat protected against hemorrhage but not death.
Get full access to this article
View all access options for this article.