Abstract
Summary
The fibrinogen concentration ratio between the thoracic duct lymph and the arterial plasma averages 0,41 in 10 dogs under pentobarbital anesthesia. Intravenous injection of endotoxin caused an increase of this L/P ratio to 0.7-0.8 which was sustained for at least 3 hours after endotoxin. The increase in the LP ratio for fibrinogen is associated with a rise in lymph flow, indicating a marked increase in capillary permeability to this protein. The increase in L/P ratio after endotoxin is due primarily to an increase in. lymph concentration, although there is a later decrease in plasma concentration. The decrease in plasma fibrinogen concentration is only partially due to fluid shifts and there is indication that specific decrease of fibrinogen concentration commences 30 minutes after endotoxin.
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