Abstract
Summary
Large basophilic cells in the lymphoid nodule of spleen are damaged when actinomycin D is given before, with, or after injection of sheep erythrocytes. The severity of cytotoxicity is dependent upon the time the drug is given in relation to injection of antigen. Consonant with the relative degree of damage is delay in appearance of circulating hemagglutinin. The time for injection of animals for maximal delay in appearance of hemagglutinin and coincident maximal cytotoxicity is 4 to 8 hours before injection of antigen.
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