Abstract
Summary
Phosphorus in various forms was determined in the subcellular fractions of skeletal muscle from mice with hereditary muscular dystrophy and from their normal littermates as controls. Total phosphorus increased in the nuclear-myofibrillar fraction and decreased in the supernatant, with a net increase for the homogenate. Acid-soluble phosphorus behaved similarly, but did not significantly increase in the homogenate. Lipid phosphorus decreased in mitochondria and increased in supernatant. In the nuclear-myofibrillar fraction, phosphorus of both deoxy- and ribonucleic acids was considerably increased, whereas, in the microsomes, only that of the ribonucleic acid was increased.
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