Abstract
Summary
Experiments on acutely prepared anesthetized dogs revealed that 17-OHCS secretion after adrenal vein cannulation reached a low baseline level within one hour and remained relatively stable for the next 3.5 hours during which time the adrenal cortex was responsive to exogenous ACTH. Using this preparation, 17-OHCS secretory rates were significantly increased during hyperoxia, hypoxia and continuous positive pressure breathing. No significant positive correlations between steroid concentration and plasma flow were observed. The possible mechanism (s) for stimulation of the adrenal cortex during these stresses are discussed.
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