Abstract
Summary
Simultaneous injection of indocyanine green dye and C14 5-HT was done in dogs to determine the extent of pulmonary removal of 5-HT. Cardiac output determined from C14 data was consistently higher than by the dye method, indicating immediate removal of 5-HT in the pulmonary bed. The mean removal was 33%, and was not changed by prior administration of β-phenylisopropylhydrazine, a monoamine oxidase inhibitor.
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