Effect of Dietary Sodium Restriction on Adrenal Cortical Response to ACTH. ∗

Abstract

Summary

In dogs fed a low sodium diet for 5 days before being hypophysectomized and nephrectomized, ACTH exerts a greater aldosterone-stimulating effect than it does in dogs fed approximately 40 mEq of sodium/day. Longer periods of sodium restriction produce a further increase in this action of ACTH. Seventeen-hydroxycorticoid output in response to various ACTH doses is unaffected.