In vitro Production of Coagulation Factors VII-X by Liver Slices from Rats Fed Atherogenic Diets. ∗

Abstract

Conclusion and summary

Coagulation Factor VII-X production by liver slices was studied because it was found that plasma Factor VII-X levels were significantly elevated in rats fed atherogenic diets. Although unexplained variations occurred, in 15 out of 18 paired experiments the production of Factor VII-X during incubation was greater in flasks containing liver slices from test animals than from controls. Expressed as a ratio (test:control) the median value of Factor VII-X production per mg protein in the flask was 1.9. Thus there appeared to be increased synthesis of Factor VII-X in flasks from test rats though the possibility of delayed degradation was not excluded.