Post-Heparin Lipolytic Activity Following Intravenous Heparin-S 35

Abstract

Summary

Following intravenous injection of S³⁵-labelled heparin in doses from 0.1–0.6 mg/kg, in rabbits, the time course of heparin radioactivity and lipolytic activity was measured. After 10 minutes, both S³⁵ and lipolytic activity decay curves follow an essentially similar course whether prolonged by larger doses of heparin or a previous 24-hour fast. These data suggest a circulating combination between these two substances. The data are not compatible with previous studies which suggested a much faster rate of turnover for heparin.