Abstract
Summary
Rabbits treated with D-L peni-cillamine beginning one day prior to intravenous injection of I131 labeled human serum albumin showed suppression of the immune response. Two-thirds of the animals completely failed to undergo immune elimination of the antigen and to form circulating antibody. The remaining ⅓ of the animals in which immunity did occur exhibited retardation of the onset of antibody synthesis. This observation contrasts with an earlier study in which the drug, if administered for 28 days before sensitization, resulted in accelerated onset of immune responsiveness.
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