Abstract
Conclusion
It may be concluded that the metabolic changes noted in in vitro incubations of bone from animals treated with PTE probably reflect the osseous action of the hormone and are not secondary to changes in level of calcium ion or release of calcitonin or thyrocalcitonin. The specific activity of matrix hydroxyproline is decreased and the specific activity of matrix hexosamine is increased in incubation of bone shortly following injection of PTE. Lactate production is enhanced and glucose uptake may be increased by the hormone. The level of equilibration of medium calcium may reflect the level of calcium bathing the bones at death of the animal.
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