Abstract
Summary
Eight antibody-negative and 3 antibody-positive adult volunteers were inoculated with ECHO virus, type 25. Infection of antibody-negative individuals resulted in respiratory illness in 4 volunteers. The illnesses which were associated with low-grade fever in 3 men were characterized by pharyngitis and cervical adenitis. Inoculation of antibody-positive individuals failed to cause illness but was associated with limited virus shedding in 2 of 3 subjects.
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