Abstract
Summary
The febrile reactivity to endo-toxin before and after malaria was studied in normal human volunteers. Four of the 5 subjects who developed malaria showed unequivocal diminution of febrile response. Two of 3 other inoculated subjects developed hepatosplenomegaly, but none of these 3 had parasitemia, nor did they exhibit endotoxin tolerance. Preliminary studies in the latter 3 men and one other who had malaria and developed endotoxin tolerance revealed no changes in the phagocytic capacity of the reticuloendothelial system. Some of the possible mechanisms of malaria induced tolerance are discussed.
We wish to express our thanks to Mr. James V. Bennett, Director of U. S. Federal Bureau of Prisons, and to Dr. Charles Smith, Medical Director, for permission to carry out these studies. We are indebted to Mr. Deaner Lawless for expert technical assistance and to Messrs. W. H. Briner and J. Meisler for aid in preparing the labeled aggregated albumin, which was generously supplied by the Squibb Laboratories. Lipexal was supplied by Dr. Fred H. Schultz, Jr., Dorsey Laboratories, Lincoln, Nebr. We are grateful to Drs. H. N. Wagner, Jr. and M. Iio, for providing aggregated albumin and helpful advice.
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