Abstract
Summary
The role of pancreatic juice in fat digestion and absorption was investigated by studying the intestinal intraluminar and mucosal lipid changes which occur after feeding cottonseed oil triglycerides to normal dogs and dogs deprived of pancreatic juice by partial pancreectomy. As based on the low concentrations of intraluminar free fatty acids and monoglycerides, intestinal digestion of cottonseed oil by the depancreatized dogs was considerably less than normal. It is concluded that, relative to pancreatic lip-ase, other sources of gastrointestinal lipase activity contribute only to a minor extent to the hydrolysis of fat. The composition of mucosal lipids of dietary origin, which consisted primarily of higher glycerides, was the same for normal and depancreatized dogs. This result suggests that intercellular esterifi-cation of the absorbed products of fat digestion is normal in the absence of pancreatic juice.
The authors express their appreciation to John Buchanan for technical assistance in various phases of this study.
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