Abstract
Summary
Severe proteinuria with considerable gamma globulin content was produced in rats by aminonucleoside injections. Sections of their kidneys at intervals between 4 and 12 days after onset of proteinuria did not show immunofluorescent staining for gamma globulin and complement. Rats made nephritic by injection of anti-rat kidney rabbit serum showed immediate morphologic damage and proteinuria with considerable gamma globulin content. Rabbit gamma globulin can be demonstrated immediately on the glomeruli while rat gamma globulin does not appear before the seventh day of disease. A kidney biopsy of a patient with multiple myeloma and advanced renal damage did not show immune staining for gamma globulin and complement, in spite of a severe proteinuria with large amounts of albumin, Bence-Jones protein and gamma globulin in the urine. Positive immune staining for gamma globulin or complement and its components in renal diseases can therefore not be attributed to trapping or unspecific transudation in the damaged kidney.
Get full access to this article
View all access options for this article.