Abstract
Summary
A semiquantitative assay for endogenous pyrogen in serum is described. The test depends on using at least 3-4 recipients at at least 4 ranges of dosage, and the use of the fever index rather than height of the fever curve. This permits construction of a dose response curve which delineates the sensitive range of pyrexia. The minimum pyrogenic dose can then be calculated and should serve as a useful standard for comparison of different pyrogenic substances.
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