Abstract
Summary
The object of the present study was to prove that rat-liver tissue will convert either estrone or estradiol to estriol in vitro and to study and compare the extent of this conversion by liver tissue from male, female, and castrated rats and the effect on this conversion of treatment of the animals with sex hormones. While there is no doubt as to the in vitro conversion of estradiol and estrone to estriol, which amounts to about 30 to 40%, there are no statistically significant effects of gonadectomy or treatment with sex hormones on rate of. conversion. A significantly larger conversion of estrone to estriol was observed in livers from male rats than in those from females.
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