Effect of Bile Duct Cannulation on Plasma Lipoproteins. ∗

Abstract

Summary

The effect of bile duct cannulation on the plasma lipoproteins was markedly influenced by the type and level of dietary fat and by the age of the birds. The low density lipoprotein level of cannulated chicks fed 1 % fat decreased, while the level in cannulated chicks fed 10% fat increased; the greater increase occurred in the group fed corn oil. High density lipoprotein levels were unaffected. The increases in level of low density lipoproteins in the chicks fed 10% fat were followed by a stationary period and by a gradual decline as observed in cannulated adult birds.

The fatty acid composition of the lipoproteins also changed after cannulation. In all cannulated birds except those fed 10% corn oil the linoleic acid content of the low density lipoproteins decreased. Fatty acid composition of the high density lipoproteins showed closely parallel changes. The mixed fatty acid composition of the bile from cannulated chicks and that from corresponding serum lipoproteins of non-cannulated chicks were very similar.