Abstract
Summary
Activity of liver phosphorylase in normal rats decreased after 4 days of fasting-by about two-thirds and recovered slowly on refeeding, whereas that of transglucosylase was not markedly affected. The glucose-6-phosphate-independent activity of transglucosylase was also only slightly influenced by fasting and feeding.
In Aminonucleoside nephrotic rats, the activities of phosphorylase and transglucosylase and the content of liver glycogen exhibited a pattern of variations probably caused by a prolonged recovery from undernutrition following the injections or due to a direct effect of the drug. Absence of similar changes in animals rendered nephrotic by kidney anti-serum is not compatible with the theory that the metabolic adjustments of the nephrotic state are associated with changes in the activity of enzymes of glycogen metabolism.
The authors are indebted to Mrs. Hanna Schramm and Mr. Eran Graff for skilled assistance.
We gratefully acknowledge the supply of Aminonucleoside of Puromycin obtained through Dr. A. Heltai of Cyanamid International, Pearl River, N. Y., and of a sample of Kidney Antiserum from Dr. J. H. Baxter, Nat. Heart. Inst.
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