Abstract
Summary
1. Phosphorylation associated with the oxidation of succinate is significantly higher in aminonucleoside-nephrotic rat liver mitochondria than in normal rat liver mitochondria. This alteration is induced as early as the 4th day during a 10-day period of induction of the disease with aminonucleo-side. 2. Phosphorylation associated with the oxidation of a-ketoglutarate, malate, fuma-rate, and β-hydroxybutyrate is not significantly altered in liver mitochondria of the aminonucleoside-nephrotic rat. 3. Phosphorylation associated with the oxidation of succinate is also increased in normal rat liver mitochondria incubated directly with aminonucleoside. In similar experiments conducted with rat liver submitochondrial phosphorylating complexes, however, aminonucleoside inhibits oxidative phosphorylation.
We are indebted to Dr. J. M. Ruegsegger, Lederle Medical Research Section, American Cyanamid Co., for aminonucleoside used in this study.
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