Abstract
Summary
Cecectomized rabbits (removal of appendix and all of cecum except proximal 3 segments) were challenged intravenously with highly purified staphylococcal entero-toxin. Diarrhea was induced in cecectomized rabbits in doses ineffective for normal rabbits. Average latency was 1¾ hours with recovery from diarrhea within 24 hours. Successive weekly injections of enterotoxin resulted in development of resistance. Pre-treatment of cecectomized rabbits with atro-pine or pyribenzamine gave definite but incomplete protection against enterotoxin-in-duced diarrhea.
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