Studies on 2-Deoxy-D-Glucose-Induced Hyperglycemia. ∗

Abstract

Summary

Small doses of 2-deoxy-D-glucose were injected into the pancreatoduodenal artery or into the femoral vein of normal dogs. The route of administration did not markedly affect the intensity and duration of the hyperglycemic response. The response was prevented by pre-treatment with dihydroergotamine. It is concluded that 2-DG does not stimulate the release of glucagonlike materials from the pancreas and that, probably, the observed hyperglycemia was due to secretion of epinephrine and inhibition of glucose utilization. No evidence of insulin release was obtained in these experiments.