Abstract
Summary
Transketolase activity in rat liver and red blood cells is decreased at a significantly slower rate than circulating or tissue thiamine in dietary-induced thiamine deficiency; superimposition of carbon tetrachloride-induced liver necrosis on thiamine deficiency increases the disparity between alterations of vitamin and enzyme levels. Replacement therapy in thiamine deficient animals with a normal liver only slowly restores tissue thiamine and transketolase; in the presence of active liver necrosis low tissue vitamin and enzyme levels persist despite administration of thiamine.
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