Effects of Growth Hormone on Glucose-U-C 14 Metabolism in Dog. ∗

Abstract

Summary

The effect of growth hormone on some aspects of glucose-U-C¹⁴ has been studied in dog. Administration of growth hormone (1 mg/kg/day) to dogs for one week was accompanied by an increase in glycogen content of the liver and ventricular myocardium. In vitro studies using slices of liver and heart tissue from control and growth hormone treated dogs showed a decrease in oxidation of glucose-U-C¹⁴ and an increased incorporation of C¹⁴ into glycogen by both tissues from growth hormone treated dogs. A small increase in the radioactivity of liver proteins from growth hormone treated dogs was also observed.