Abstract
Summary
6-azauridine, an inhibitor of RNA metabolism, has been found to inhibit the synthesis of the DNA-containing vaccinia virus. The inhibition can be specifically removed by addition of uridine. The essential participation of RNA occurs early during the infectious sequence and is completed at about 6 hours after infection. Studies on vaccinial antigens and DNA production indicated that these biologic units are all dependent upon the production of this early RNA component.
The author wishes to acknowledge the very capable technical assistance of Miss Marge Soergel.
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