Abstract
Summary
Increased erythropoietic specific activities remained in urine which had been concentrated by flash evaporation, adjusted to high ionic strength, and precipitated at high ethanol concentration. The apparent stability of erythropoietin was attributed to a protective carrier relatively stable under the conditions described. Erythropoietic activity from urine concentrate was detected in the dialyzate from a membrane which retained thyrotropic hormone and allowed glucagon to escape. The dialysis data added credence to the postulate of a free and bound erythropoietin.
The authors are indebted to Miss Dorothy A. Alford for helpful assistance.
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