Abstract
Summary
Findings relative to the pathogenesis of SV40 virus in inducing tumor in hamsters are discussed. Infectious virus disappeared rapidly from the animal and was not demonstrable until its appearance in tumor. The quantity of virus was related to tumor size. Infectious virus was commonly demonstrable in tumor but was not always present and appeared not to be essential to retention of oncogenic quality. Initial neutralizing antibody response in a portion of animals to inoculated SV40 virus appeared unrelated to subsequent development or failure to develop tumor.
The technical assistance of W. Raupp and T. Beddow is gratefully acknowledged.
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