Biopotency of l-α-Tocopheryl Acetate for the Rat. ∗

Abstract

Summary

The l epimer of α-tocopheryl acetate, appears to have approximately 20 0/0 of the biological activity of the d epimer in the rat by the criteria of growth and delay in onset of creatinuria as a sign of nutritional muscular dystrophy. The l epimer alone can replace d-a-tocopherol but only if sufficient is supplied. No evidence of synergism or sparing action was observed.

We wish to thank Dr. Stanley Ames of Distillation Products Industries for the generous gift of l-α-tocopherol acetate and Una Barnett for performing the creatine and creatinine determinations.