Abstract
Summary
1. 5-Hydroxytryptophan (5-HTP) given parenterally to cats exerts emesis. This effect is enhanced by various monoamine oxidase inhibitors and blocked by pentobarbital. 2. The emetic effect of 5HTP is antagonized by chlorpromazine and by compounds that deplete brain catecholamines (reserprine, α-methyl DOPA and α-methyl-m-tyrosine) suggesting that 5HTP acts through release of norepinephrine.
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